Human RFNG activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RFNG
Locus ID	5986
Kit Components	GA104080G1, RFNG gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104080G2, RFNG gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104080G3, RFNG gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_002917
Synonyms	beta-1,3-N-acetylglucosaminyltransferase radical fringe; radical fringe homolog; RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Summary	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis.[UniProtKB/Swiss-Prot Function]

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