Human Nav1.6 (SCN8A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SCN8A
Locus ID	6334
Kit Components	GA104299G1, Nav1.6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104299G2, Nav1.6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104299G3, Nav1.6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001177984, NM_014191, NM_001330260, NM_001369788
Synonyms	CERIII; CIAT; EIEE13; MED; NaCh6; Nav1.6; PN4
Summary	This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

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