Human Topoisomerase III alpha (TOP3A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TOP3A
Locus ID	7156
Kit Components	GA104941G1, Topoisomerase III alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104941G2, Topoisomerase III alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104941G3, Topoisomerase III alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001320759, NM_004618
Synonyms	TOP3; ZGRF7
Summary	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

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