Human UBE2L3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	UBE2L3
Locus ID	7332
Kit Components	GA105050G1, UBE2L3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105050G2, UBE2L3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105050G3, UBE2L3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001256355, NM_001256356, NM_003347, NM_198157, NR_028436, NR_028437, NR_046082
Synonyms	E2-F1; L-UBC; UBCH7; UbcM4
Summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

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