Human ZFAND5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZFAND5
Locus ID	7763
Kit Components	GA105296G1, ZFAND5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105296G2, ZFAND5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105296G3, ZFAND5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001102420, NM_001102421, NM_001278243, NM_001278244, NM_001278245, NM_006007
Synonyms	ZA20D2; ZFAND5A; ZNF216
Summary	Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.[UniProtKB/Swiss-Prot Function]

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