Human MAP3K12 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MAP3K12
Locus ID	7786
Kit Components	GA105314G1, MAP3K12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105314G2, MAP3K12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105314G3, MAP3K12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001193511, NM_006301
Synonyms	DLK; MEKK12; MUK; ZPK; ZPKP1
Summary	This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

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