Human PAX8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PAX8
Locus ID	7849
Kit Components	GA105334G1, PAX8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105334G2, PAX8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105334G3, PAX8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_003466, NM_013951, NM_013952, NM_013953, NM_013992
Synonyms	OTTHUMP00000158659; OTTHUMP00000158660; paired box 8; paired domain gene 8
Summary	This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

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