Human SPOP activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SPOP
Locus ID	8405
Kit Components	GA105552G1, SPOP gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105552G2, SPOP gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105552G3, SPOP gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001007226, NM_001007227, NM_001007228, NM_001007229, NM_001007230, NM_003563, NM_001370730, NM_001370731, NM_001370732
Synonyms	BTBD32; TEF2
Summary	This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

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