Human Cullin 4B (CUL4B) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CUL4B
Locus ID	8450
Kit Components	GA105582G1, Cullin 4B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105582G2, Cullin 4B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105582G3, Cullin 4B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001079872, NM_003588, NM_001330624, NM_001369145
Synonyms	CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2
Summary	This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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