Human ALDH1A2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ALDH1A2
Locus ID	8854
Kit Components	GA105893G1, ALDH1A2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105893G2, ALDH1A2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105893G3, ALDH1A2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001206897, NM_003888, NM_170696, NM_170697
Synonyms	RALDH(II); RALDH2; RALDH2-T
Summary	This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]

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