Human RAB7L1 (RAB29) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RAB29
Locus ID	8934
Kit Components	GA105954G1, RAB7L1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105954G2, RAB7L1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105954G3, RAB7L1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001135662, NM_001135663, NM_001135664, NM_003929
Synonyms	RAB7L; RAB7L1
Summary	Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.[UniProtKB/Swiss-Prot Function]

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