Human ASC1 (TRIP4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TRIP4
Locus ID	9325
Kit Components	GA106215G1, ASC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106215G2, ASC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106215G3, ASC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001321924, NM_016213, NR_135855
Synonyms	ASC-1; ASC1; HsT17391; MDCDC; SMABF1; ZC2HC5
Summary	This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]

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