Human CNOT8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CNOT8
Locus ID	9337
Kit Components	GA106224G1, CNOT8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106224G2, CNOT8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106224G3, CNOT8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001301073, NM_001301074, NM_001301075, NM_001301077, NM_001301080, NM_001301082, NM_001301083, NM_001301086, NM_004779
Synonyms	CAF1; Caf1b; CALIF; hCAF1; POP2
Summary	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.[UniProtKB/Swiss-Prot Function]

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