Human Klotho (KL) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	KL
Locus ID	9365
Kit Components	GA106246G1, Klotho gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106246G2, Klotho gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106246G3, Klotho gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_004795, NM_153683
Synonyms	klotho; OTTHUMP00000018796
Summary	This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]

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