Human NCoR (NCOR1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NCOR1
Locus ID	9611
Kit Components	GA106435G1, NCoR gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106435G2, NCoR gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106435G3, NCoR gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001190438, NM_001190440, NM_006311
Synonyms	hN-CoR; N-CoR; N-CoR1; PPP1R109; TRAC1
Summary	This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

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