Human RGS6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RGS6
Locus ID	9628
Kit Components	GA106448G1, RGS6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106448G2, RGS6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106448G3, RGS6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001204416, NM_001204417, NM_001204418, NM_001204419, NM_001204420, NM_001204421, NM_001204422, NM_001204423, NM_001204424, NM_004296, NR_135235, NM_001370270, NM_001370271, NM_001370272, NM_001370273, NM_001370274, NM_001370276, NM_001370278, NM_001370281, NM_001370284, NM_001370290, NM_001370275, NM_001370277, NM_001370279, NM_001370280, NM_001370282, NM_001370283, NM_001370286, NM_001370287, NM_001370288, NM_001370289, NM_001370291, NM_001370292, NM_001370293, NM_001370294
Synonyms	GAP
Summary	This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]

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