Human FISH (SH3PXD2A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SH3PXD2A
Locus ID	9644
Kit Components	GA106461G1, FISH gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106461G2, FISH gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106461G3, FISH gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_014631, NM_001365079
Synonyms	FISH; SH3MD1; TKS5
Summary	Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.[UniProtKB/Swiss-Prot Function]

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