Human SETDB1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SETDB1
Locus ID	9869
Kit Components	GA106659G1, SETDB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106659G2, SETDB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106659G3, SETDB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001145415, NM_001243491, NM_012432, NR_026977, NM_001366417, NM_001366418
Synonyms	ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21
Summary	This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]

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