Human Lubricin (PRG4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PRG4
Locus ID	10216
Kit Components	GA106946G1, Lubricin gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106946G2, Lubricin gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106946G3, Lubricin gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001127708, NM_001127709, NM_001127710, NM_001303232, NM_005807
Synonyms	CACP; HAPO; JCAP; MSF; SZP
Summary	The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

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