Human PGC1 alpha (PPARGC1A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PPARGC1A
Locus ID	10891
Kit Components	GA107462G1, PGC1 alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107462G2, PGC1 alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107462G3, PGC1 alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001330751, NM_001330752, NM_001330753, NM_013261, NM_001354825, NM_001354826, NM_001354827, NM_001354828, NR_148981, NR_148982, NR_148983, NR_148984, NR_148985, NR_148986, NR_148987
Synonyms	LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v; PGC1; PGC1A; PPARGC1
Summary	The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

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