Human LILRB3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LILRB3
Locus ID	11025
Kit Components	GA107575G1, LILRB3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107575G2, LILRB3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107575G3, LILRB3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001081450, NM_006864, NM_001320960, NR_135493, NR_135494, NR_135495, NR_135496
Synonyms	CD85A; HL9; ILT-5; ILT5; LILRA6; LIR-3; LIR3; PIRB
Summary	This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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