Human FGFR1 Oncogene Partner (FGFR1OP) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CEP43
Locus ID	11116
Kit Components	GA107643G1, FGFR1 Oncogene Partner gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107643G2, FGFR1 Oncogene Partner gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107643G3, FGFR1 Oncogene Partner gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001278690, NM_007045, NM_194429
Synonyms	FOP
Summary	This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]

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