Human Calpain 10 (CAPN10) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CAPN10
Locus ID	11132
Kit Components	GA107657G1, Calpain 10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107657G2, Calpain 10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107657G3, Calpain 10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_021251, NM_023083, NM_023084, NM_023085, NM_023086, NM_023087, NM_023088, NM_023089
Synonyms	calcium-activated neutral protease; calpain 10; NIDDM1; OTTHUMP00000164509
Summary	Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]

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