Human PACS2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PACS2
Locus ID	23241
Kit Components	GA108154G1, PACS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108154G2, PACS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108154G3, PACS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001100913, NM_001243127, NM_015197
Synonyms	PACS-2; PACS1L
Summary	Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.[UniProtKB/Swiss-Prot Function]

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