Human KAT6B activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	KAT6B
Locus ID	23522
Kit Components	GA108366G1, KAT6B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108366G2, KAT6B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108366G3, KAT6B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001256468, NM_001256469, NM_012330, NM_001370133, NM_001370136, NM_001370140, NM_001370141, NM_001370143, NM_001370144, NM_001370132, NM_001370134, NM_001370135, NM_001370137, NM_001370138, NM_001370139, NM_001370142
Synonyms	GTPTS; MORF; MOZ2; MYST4; qkf; querkopf; ZC2HC6B
Summary	The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

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