Human Ephexin 1 (NGEF) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NGEF
Locus ID	25791
Kit Components	GA108537G1, Ephexin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108537G2, Ephexin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108537G3, Ephexin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001114090, NM_019850
Synonyms	ARHGEF27; EPHEXIN
Summary	Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).[UniProtKB/Swiss-Prot Function]

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