Human ZNF658 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZNF658
Locus ID	26149
Kit Components	GA108774G1, ZNF658 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108774G2, ZNF658 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108774G3, ZNF658 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001317916, NM_033160, NR_134255
Synonyms	DKFZp572C163; FLJ32813; MGC35232
Summary	Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply.[UniProtKB/Swiss-Prot Function]

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