Human ALP (PDLIM3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PDLIM3
Locus ID	27295
Kit Components	GA109105G1, ALP gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109105G2, ALP gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109105G3, ALP gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001114107, NM_001257962, NM_001257963, NM_014476, NR_047562
Synonyms	ALP
Summary	The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]

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