Human BLNK activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	BLNK
Locus ID	29760
Kit Components	GA109259G1, BLNK gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109259G2, BLNK gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109259G3, BLNK gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001114094, NM_001258440, NM_001258441, NM_001258442, NM_013314, NR_047680, NR_047681, NR_047682, NR_047683
Synonyms	AGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65
Summary	This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

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