Human MEMO1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MEMO1
Locus ID	51072
Kit Components	GA109538G1, MEMO1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109538G2, MEMO1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109538G3, MEMO1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001137602, NM_001301833, NM_001301852, NM_015955, NR_126032, NR_126034
Synonyms	C2orf4; CGI-27; MEMO; NS5ATP7
Summary	May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.[UniProtKB/Swiss-Prot Function]

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