Human Shwachman Bodian Diamond syndrome (SBDS) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SBDS
Locus ID	51119
Kit Components	GA109582G1, Shwachman Bodian Diamond syndrome gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109582G2, Shwachman Bodian Diamond syndrome gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109582G3, Shwachman Bodian Diamond syndrome gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_016038
Synonyms	CGI-97; SDS; SWDS
Summary	This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jan 2017]

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