Human Apc11 (ANAPC11) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ANAPC11
Locus ID	51529
Kit Components	GA109855G1, Apc11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109855G2, Apc11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109855G3, Apc11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001002244, NM_001002245, NM_001002246, NM_001002247, NM_001002248, NM_001002249, NM_001289414, NM_001289415, NM_001289416, NM_001289417, NM_001289418, NM_001289419, NM_001289420, NM_016476
Synonyms	APC11; Apc11p; HSPC214
Summary	Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.[UniProtKB/Swiss-Prot Function]

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