Human ATP6V1H activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ATP6V1H
Locus ID	51606
Kit Components	GA109899G1, ATP6V1H gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109899G2, ATP6V1H gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109899G3, ATP6V1H gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_015941, NM_213619, NM_213620
Synonyms	CGI-11; MSTP042; NBP1; SFD; SFDalpha; SFDbeta; VMA13
Summary	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

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