Human CIAO2B activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CIAO2B
Locus ID	51647
Kit Components	GA109920G1, CIAO2B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109920G2, CIAO2B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109920G3, CIAO2B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_016062, NR_024525, NR_046109
Synonyms	CGI-128; CIA2B; MIP18
Summary	Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004, PubMed:22678362, PubMed:22678361). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633).[UniProtKB/Swiss-Prot Function]

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