Human C20orf11 (GID8) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GID8
Locus ID	54994
Kit Components	GA110435G1, C20orf11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110435G2, C20orf11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110435G3, C20orf11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_017896
Synonyms	C20orf11; TWA1
Summary	Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046).[UniProtKB/Swiss-Prot Function]

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