Human BTBD7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	BTBD7
Locus ID	55727
Kit Components	GA110916G1, BTBD7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110916G2, BTBD7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110916G3, BTBD7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001002860, NM_001289133, NM_018167
Synonyms	FUP1
Summary	Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).[UniProtKB/Swiss-Prot Function]

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