Human Sulfatase 2 (SULF2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SULF2
Locus ID	55959
Kit Components	GA111071G1, Sulfatase 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111071G2, Sulfatase 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111071G3, Sulfatase 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001161841, NM_018837, NM_198596
Synonyms	HSULF-2
Summary	Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

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