Human DIABLO activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DIABLO
Locus ID	56616
Kit Components	GA111199G1, DIABLO gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111199G2, DIABLO gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111199G3, DIABLO gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001278302, NM_001278303, NM_001278304, NM_001278342, NM_019887, NM_138929, NM_138930, NR_024600, NR_024601, N66735
Synonyms	DFNA64; SMAC
Summary	This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

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