Human MRTFA activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MRTFA
Locus ID	57591
Kit Components	GA111616G1, MRTFA gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111616G2, MRTFA gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111616G3, MRTFA gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001282660, NM_001282661, NM_001282662, NM_001318139, NM_020831
Synonyms	BSAC; MAL; MRTF-A
Summary	The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

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