Human IKB zeta (NFKBIZ) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NFKBIZ
Locus ID	64332
Kit Components	GA112042G1, IKB zeta gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112042G2, IKB zeta gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112042G3, IKB zeta gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001005474, NM_031419
Synonyms	IKBZ; INAP; MAIL
Summary	This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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