Human CSN7b (COPS7B) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	COPS7B
Locus ID	64708
Kit Components	GA112107G1, CSN7b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112107G2, CSN7b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112107G3, CSN7b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001282949, NM_001282950, NM_001282951, NM_001282952, NM_001308381, NM_022730, NM_001369483
Synonyms	CSN7B; SGN7b
Summary	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.[UniProtKB/Swiss-Prot Function]

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