Human Apoptosis enhancing nuclease (AEN) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	AEN
Locus ID	64782
Kit Components	GA112143G1, Apoptosis enhancing nuclease gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112143G2, Apoptosis enhancing nuclease gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112143G3, Apoptosis enhancing nuclease gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_022767
Synonyms	ISG20L1; pp12744
Summary	Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.[UniProtKB/Swiss-Prot Function]

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