Human DEM1 (EXO5) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	EXO5
Locus ID	64789
Kit Components	GA112150G1, DEM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112150G2, DEM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112150G3, DEM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_022774, NM_001346946, NM_001346947, NM_001346948, NM_001346949, NM_001346950, NM_001346951, NM_001346952, NM_001346953, NM_001346954, NM_001346955, NM_001346956
Synonyms	C1orf176; DEM1; Exo V; hExo5
Summary	The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016]

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