Human UPF3B activation kit by CRISPRa
CAT#: GA112238
UPF3B CRISPRa kit - CRISPR gene activation of human UPF3B regulator of nonsense mediated mRNA decay
CNY 12255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | UPF3B |
Locus ID | 65109 |
Kit Components | GA112238G1, UPF3B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112238G2, UPF3B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112238G3, UPF3B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_023010, NM_080632 |
Synonyms | HUPF3B; MRX62; MRXS14; RENT3B; UPF3BP1; UPF3BP2; UPF3BP3; Upf3p-X; UPF3X |
Summary | This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN421466 | UPF3B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |