Human MRI (C7orf49) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CYREN
Locus ID	78996
Kit Components	GA112297G1, MRI gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112297G2, MRI gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112297G3, MRI gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001243749, NM_001243751, NM_001243752, NM_001243753, NM_001243754, NM_001243755, NM_001305629, NM_001305630, NM_024033, NR_024185, NR_024186, NM_001363329, NM_001363330
Synonyms	MRI
Summary	Isoform 1: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974). May act as a regulator of proteasome (By similarity).[UniProtKB/Swiss-Prot Function]

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