Human TUG (ASPSCR1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ASPSCR1
Locus ID	79058
Kit Components	GA112340G1, TUG gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112340G2, TUG gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112340G3, TUG gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001251888, NM_001330528, NM_024083, NR_045351
Synonyms	ASPCR1; ASPL; ASPS; RCC17; TUG; UBXD9; UBXN9
Summary	The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]

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