Human EFTUD1 (EFL1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	EFL1
Locus ID	79631
Kit Components	GA112503G1, EFTUD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112503G2, EFTUD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112503G3, EFTUD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001040610, NM_001322844, NM_001322845, NM_024580, NR_136410
Synonyms	EFTUD1; FAM42A; HsT19294; RIA1
Summary	Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.[UniProtKB/Swiss-Prot Function]

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