Human HSD3B7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HSD3B7
Locus ID	80270
Kit Components	GA112898G1, HSD3B7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112898G2, HSD3B7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112898G3, HSD3B7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001142777, NM_001142778, NM_025193
Synonyms	CBAS1; PFIC4; SDR11E3
Summary	This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

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