Human TXNDC5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TXNDC5
Locus ID	81567
Kit Components	GA113071G1, TXNDC5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113071G2, TXNDC5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113071G3, TXNDC5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001145549, NM_022085, NM_030810
Synonyms	ENDOPDI; ERP46; HCC-2; PDIA15; STRF8; UNQ364
Summary	This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

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