Human RNF170 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RNF170
Locus ID	81790
Kit Components	GA113119G1, RNF170 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113119G2, RNF170 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113119G3, RNF170 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001160223, NM_001160224, NM_001160225, NM_030954, NR_027668, NR_027669
Synonyms	ADSA; SNAX1
Summary	This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

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